Category: Bioactive Compound Library

Bone morphogenetic protein 2, a member of the TGF-b superfamily, has been implicated in the development of the skeleton, kidney and pancreas. It functions by binding to the type II receptor and recruiting a type I receptor, then phosphorylating intracellular substrates, i.e., Smad1, Smad5, and Smad8, which form complex with Smad4, translocate into the nucleus… Continue reading Endocrine dysfunction is effective in the treatment of rat renal fibrosis induced by unilateral urethral obstruction

In this study, we proved that the down-regulation of HMGB1 inhibits the invasion of HCCLM6 cells, whereas the up-regulation of HMGB1 enhances the invasion of HCCLM3 cells. In summary, our study evaluated the prognostic significance of HMGB1 expression in numerousspecimens of HCC clinical tissues. As these patients we selected are at early or intermediate stage… Continue reading Systemic blockade of TGF-b can cause detrimental problems due to the broad spectrum of biological functions of TGF-b

Although the mutants showed no difference from the wild-type protein, these negative results only indicate that the variations did not affect these specific features in certain cells. Indeed, the variants might impair the function of DLC1 in other ways or in other cardiac cells. Furthermore, to the best of our knowledge, this is the first… Continue reading Embryos have a sequenced DLC1 isoform 1 and the mutants had similar prohibitive effects on angiogenesis

However, we should note that, the reference variant data from the 1000 Genomes Project and the Exome Sequencing Project were produced by different platforms, most of which were next generation sequencing platforms. The sequencing depth, coverage and data analysis pipelines might affect the variant detection rate. It is the consideration that the variant number from… Continue reading Considering that endocardium formation in the primitive heart tube is affected by vasculogenesis

Recently, honey has been tested and approved scientifically for its functional and biological properties such as anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-ulcerous activities and anti-cancer properties. Honey may provide a basis for the development of novel adjuvant for patients with glioma. Recent studies showed a significant anticancer activity of Malaysian jungle honey on human breast, cervical,… Continue reading It should be noted that we have found a significant correlation between TPC and the viability of cells