Thus, NA14 could conceivably play a role in cytokinesis by regulating the localization and the microtubule-severing activity of spastin at the midbodies. Of possible relevance, NA14 expression is upregulated in T-cell acute lymphoblastic leukemia characterized by an amplification of 9q34 and is differentially expressed in pancreatic cancer. Several groups have shown that spastin influences microtubule… Continue reading Particularly in the pathogenesis of the NA14-interacting protein spastin that is also highly enriched at midbodies
Category: Bioactive Compound Library
The effect of APS on LDLR was further reducing the capacity of micelles to incorporate cholesterol
It has been proved that the viscosity associated with dietary soluble polysaccharides interferes with cholesterol absorption by directly binding cholesterol within the intestine, interfering with the diffusion of cholesterol toward the epithelial cell surface. We thus propose the reduction of cholesterol absorption in response to APS maybe attributed to its viscosity, with little regulation of… Continue reading The effect of APS on LDLR was further reducing the capacity of micelles to incorporate cholesterol
MSCs are valuable as a therapeutic tool as they are hardly immunogenic due to circumvent the limitation
The local ethics committee that allowed us to perform liver biopsy only on a limited group of patients with clinical signs of impaired liver function at the enrolment in the trial. After NLCD, TGF-b serum concentration significantly decreased in CHC patients and not in NAFLD/NASH patients. To note, the TGF-b is not produced exclusively by… Continue reading MSCs are valuable as a therapeutic tool as they are hardly immunogenic due to circumvent the limitation
During antiviral therapy pressure limited number of variants carrying resistant mutations emerge and predominate
The Sn in preCore/Core was significantly higher at B than at TNR, and was non-significantly higher in TF than at TNR. These findings suggest a decrease in QA evolution, associated with LVD treatment failure. Boni et al reported that the immune response is enhanced when antiviral treatment controls HBV replication, but our patients were treatment… Continue reading During antiviral therapy pressure limited number of variants carrying resistant mutations emerge and predominate
The advantages of claims-based studies compared with collecting information from reports or medical chart
Nearly 20% of patients in our study population had no adherence assessment and counseling form completed. That these very patients tended to have lower adherence levels by pharmacybased refill data, indicates that providers seemed to be missing patients with high levels of need. When resources are constrained, using the information about which patients are at… Continue reading The advantages of claims-based studies compared with collecting information from reports or medical chart