Category: Bioactive Compound Library

This excluded lactate dehydrogenase, which was shown here to be unaffected by the NaB. In order to maintain a high rate of glycolysis, it is mandatory for the tumor cells to have access to a ready supply of glucose. In many types of cancers, glucose transport is performed by class 1, 3 and 4, which… Continue reading Diminished lactate release result which could have reflected a direct inhibitory effect of the HDACi

For an example, if a pathway consists of a cascade of reactions in such a way that phosphorylation is only required as its trigger, then such pathway would not be fully inhibited by SAR131675 activated PKC inhibitors. Namely, the transient PKC activity in the presence of activated PKC inhibitors would be sufficient to activate the… Continue reading Important for activated kinase inhibitors since transient activation remains in the presence of this type of inhibitor

Transfection with 9 different siRNA pools showed that Bid and Bik siRNA significantly reduced thaspin-induced cytokeratin 18 caspase-cleavage in HCT116 cells, suggesting that these proteins are regulators of apoptosis elicited by this compound. Topoisomerase inhibition was tested using in vitro enzyme assays. The results showed that thaspine inhibits both topoisomerase I and II activity at… Continue reading Whether any particular BH3only proteins were required for thapsin-induced apoptosis

With the growing tools of small molecules, the modulation of these networks of interactions represents a promising therapeutic strategy. Protein-protein interaction inhibitors are certainly the next generation of highly innovative drugs that will reach the market in the next decade. As a consequence of this enthusiasm, the exponential increase of published biomedical literature on PPIs… Continue reading In understanding biological pathways host-pathogen interactions and cancer development

STAT5A1*6 has two amino acid substitutions and it is constitutively phosphorylated, localized in the cell nucleus and transcriptionally active in the absence of IL-3. In the BaFiso system presented here, the protective potential of myr-Akt is slightly greater than that provided by STAT5A1*6, which may be explained by the greater expression of myr-Akt. The design… Continue reading Corticospinal degeneration leads to a retrovirus encoding an activated mutant of STAT5