Over time, management of SLE patients has improved and life expectancy of these patients has increased to reach a 10-year survival rate about 70%. However, several studies have revealed that atherosclerosis-attributed vascular events are significantly more frequent in these surviving lupus patients, compared to age-related individuals without SLE. Atherosclerosis is characterized by a chronic inflammatory… Continue reading Chronic inflammation has been implicated as a contributing involving multiple organs that is characterized by autoantibody production and chronic inflammation

Pompe disease is a lysosomal storage disorder in which a deficiency of acid a-glucosidase causes glycogen accumulation in all tissues, particularly cardiac and skeletal muscle. Microscopic analyses of muscle tissue typically show accumulation of glycogencontaining vacuoles in the myocytes. Pompe disease presents with a wide spectrum of phenotypes, ranging from a severe and rapidly progressive… Continue reading Serum creatine kinase has not been shown to be useful for monitoring treatment effects

A variety of programs and treatments including drug therapeutics, surgical intervention and dietary control for obesity management or prevention have been developed; however, these are often associated with safety issues. Therefore, the development of a safe and effective dietary supplement to assist with body weight management is essential. Lactobacilli and bifidobacteria are representative probiotic microorganisms… Continue reading Low energy expenditure are the main causes of obesity as well as metabolic disorders

In terms of ROS production, DNA damage, and cardiomyocyte apoptosis in cardiomyocyte cell culture in vitro as well as in the mouse in vivo. We found a reduction in LVEF that was significantly less with epirubicin and non-pegylated liposomal-doxorubicin as compared to standard doxorubicin. Furthermore, we found that epirubicin reduces the heart rate to a… Continue reading Standard doxorubicin preparation in comparison with both epirubicin and liposomaldelivered doxorubicin

We, consequently, evaluated the differential impact of D313Y on clinical manifestations and concluded that D313Y might broaden the spectrum of hereditary small artery diseases of the brain which preferably occur,45 years of age and should be more specifically taken into account in patients with multifocal WML in the absence of classical risk factors. The widespread… Continue reading Potentially causing manifest WML as cerebral manifestations of FD