This highlights the importance of using robust methodologies that adjust for potential effect modifiers in comparisons of RCTs. Drawing conclusions based on raw data may be misleading. The results of the analysis were robust to changes in the included RCTs and treatment arms. Including REVEAL, excluding READ-2 and including the ranibizumab plus deferred laser arm… Continue reading Model adjusting for baseline BCVA the proportion of patients gaining was highest with ranibizumab therapy

Examination of the memory and executive scores of the CPAL indicated that the memory and executive components of associate learning were affected differently by memory load under conditions where pattern-location associations exceed working memory capacity. That memory and executive functions are necessary for associate learning is consistent with data from an extensive neuropsychological literature in… Continue reading This is consistent with the results of other studies that have examined the development of learning reported previously

The N-terminal actin binding domain is followed by four tandem spectrin repeats and a calmodulin-like domain, that determines each isoform’s calcium sensitivity, at its Cterminus. Although three of the four a-actinin isoforms, aactinin-1, -2, and -4, have been identified in rat PSD fractions by mass spectrometry and RT-PCR of cultured hippocampal neurons, immunofluorescence and electron… Continue reading Whereas previous studies show enrichment of a-actinin-2 in rat forebrain post-synaptic density fractions

HECT-containing E3 proteins with a small number in human are directly involved in catalysis: Ub is transferred from E2 to the catalytic cysteine of the HECT domain, and then to a target lysine residue. RING family members represent most of the E3s, of which there are over 600 encoded in the human genome. They possess… Continue reading With ligases dominantly fall into two sub classes bearing either a HECT domain or a RING domain

Immunized with gD2-alum/MPL twice or three times at a dose of 5 mg of gD2. Compared with sham immunization, immunization with the gD2-alum/MPL led to 23fold, 508-fold, 442-fold, and 23fold reduction in challenge virus replication on days 1, 2, 3, and 5 post-challenge, respectively. Significantly, immunization with CJ2-gD2 is more robust in blocking acute challenge… Continue reading We showed that immunization with MPL was very effective in protecting against HSV-2 intravaginal infection