These data correlate well with the behavioral phenotype and provide support for the interpretation that the seizure-like hyperactivity seen in the lgi1a morphants is similar to mammalian seizures. In addition, the absence of seizure-like behavior in the lgi1b morphants, even following high dose MO treatment, together with no change in fos expression, further demonstrates the distinct functions of these genes. Hypertension is an increasingly common health problem affecting currently one billion people worldwide. Although effective medicines are available to control high blood pressure, adherence to treatment remains a major problem. The extent of hypertensive patients who adhere to treatment is estimated to be 50% to 90%. Lack of treatment adherence results in suboptimal blood pressure control, adverse cardiovascular outcomes, and health care costs that could have been avoided. Researchers have identified several correlates of adherence, including patient characteristics, the quality of the patient-clinician relationship, severity of disease, access to health care, and treatment regimen. Recent studies also suggest that social support may facilitate treatment adherence. An important extension of the evidence linking social relationships to health outcomes is the growing literature on social capital and health. Social capital is defined as the features of social structures which act as resources for individuals, including interpersonal trust and norms of reciprocity and mutual aid. Both low social capital and uncontrolled blood pressure have been linked to cardiovascular disease morbidity and mortality. MDV3100 CYP17 inhibitor However it is unclear whether poor adherence to antihypertensive medication therapy could be one of the potential mechanisms linking low social capital to adverse cardiovascular outcomes. In theory, social capital may influence medication adherence through: the provision of effective social support networks for the exchange of health promoting information and access to resources outside the individual’s own network ; social engagement in a meaningful social context that promotes positive psychological states to enhance motivation for self-care and appropriate health service utilization; and shared norms and values around health-related behaviours. To date, at least two studies have examined the relationship between social capital and the use of antihypertensive medication. However, both of these studies used self-reports to assess exposure and outcome and were thus subject to common method bias. Furthermore, the studies assessed social capital via social participation in the community among working and retired people. It can be argued that for working populations spending an increasing amount of their time at work, workplace may also represent a meaningful source of social capital. However, we are not aware of any previous studies examining the hypothesis that social capital in work context may promote adherence to antihypertensive drug therapy. The aim of the present study was to examine study of 3515 hypertensive men and women who responded to a survey of workplace social capital.