However, much additional work is warranted to ascertain the roles of angiogenesis in muscle regeneration by clones of ectopic stem/progenitor cells. This appears to be consistent with weak CD133 and CD146 expression by human pericytes in muscle regeneration. Much meritorious effort has been directed towards transcriptional control of myogenic differentiation from stem/progenitor cells. The present data represent a rare glimpse of in vivo muscle repair by clonal progenies of heterogeneous stem/progenitor cells with robust capacity for myogenic differentiation in vitro. These three types of hair follicles appear sequentially during fetal development and early after birth. At day 19 of gestation, the central primary hair follicles rise followed at day 25 by the primary lateral hair follicles. At day 29 of gestation, a secondary hair follicle for each of the 2 to 4 lateral hair follicles appears. Finally, secondary derived hair follicles emerging from the skin by the same hair channel, appears during the early childhood of the animals. Normal rabbit fur is composed of three different types of hairs: guard hairs produced by central primary hair follicles, awn hairs produced by lateral primary hair follicles which both constitute the physical ����outer coat���� protection, and down hairs produced by secondary hair follicles, and the inner coat for thermal protection. Down hairs are the most abundant and represent about all hairs. In 1919, a mutant phenotype with soft short hairs was observed by a French breeder in a litter of European rabbits. We first provide evidence showing that the 1362delA LIPH mutation does not alter the histological structure of rabbit skin. Indeed, no gross abnormalities were observed after staining of skin cross sections, neither at the three fetal stages, nor in adults. Hair follicle structures were similar between Gelsemine orylagH and normal rabbits at all development stages. Likewise, no differences of hair follicle group Isovitexin density could be evidenced. These data suggest that LIPH does not play a major role in hair follicle formation and development. We then show that LIPH is expressed in three hair follicle types, mainly in the ORS and to a lesser extent in the IRS. These findings raise the question of how this LIPH mutation affects mainly primary hair follicles producing guard hair.