Indeed, the substitution of tellurium for sulfur in the active site of subtilisin results in an enzyme with novel peroxidase activity. It may be the case that, like selenite, tellurite is reduced to telluride on the same ATP carrier by the same enzymes that catalyze the assimilatory reduction of sulfite to sulfide, and that tellurite may compete with sulfite for incorporation into the active sites of oxidoreductases. Our results confirm the principle of building a modular tool from multiple mass spectrometers. The flexibility of the modular approach allows us to use the strengths of each mass spectrometer for collecting additive information about a sample in a datadependent manner. To address this question, suitable control samples from healthy persons and/or pair specimens, isolated after recovery, might be required. Another possible problem with this viral genome analysis is biased cDNA synthesis by quasi-random RT-PCR with the WTA kit. As shown in Figure S1, a significant bias was found and its pattern was identical in all samples. TG –rich regions were selectively amplified with the WTA kit , probably due to nucleotide sequences of the quasi-random primer. Random RTPCR amplification using the WTA kit was at least one log higher than that using the conventional random hexamer. This suggests that further improvement is required for whole viral genome analysis, although our system is suitable for the comprehensive detection of viral genes. In addition, the TG – rich bias was observed SCH772984 within the viral genome; therefore, it seems unlikely that the bias leads to quantitative differences of the detected sequences with respect to the original population.Although we used only MALDI mass spectrometers to demonstrate the feasibility of a modular tool, mass spectrometers operating with electrospray ion sources coupled to an HPLC system can also be combined in a modular tool. This modular concept, based on the strengths of mass spectrometers operating with both MALDI and ESI, provides an alternative and complementary route for building powerful mass spectrometric tools for the biological research.However, this model cannot explain the result that inactivation of the S. aureus cysteine synthase gene, which should block the formation of telluroproteins by this route, results in an increased sensitivity to tellurite. Catalase appears to be quite promiscuous, with two active sites that can participate in a variety of redox and condensation reactions. Tellurite is not the only heavy metal derivative that is a substrate of catalase. Both eukaryotic and prokaryotic catalases carry out the heme-dependent oxidation of metallic mercury, a reaction stimulated by hydrogen peroxide. Importantly, there have been no prospective studies of multifactorial risk factors for falling specific to the population with dementia. Previous studies have identified multiple risk factors for falls in the older population as a whole, in a variety of settings.