Also, the number of subjects with elevated albuminuria was relatively low. Additionally, nondifferential misclassification may occur because there was only one measurement of creatinine concentration or urinary protein. However, nondifferential misclassifications usually bias the results to the null and, thus, our estimates would be conservative. Although we have found a significant overall Perifosine association between high blood pressure and renal function insufficiency in all participants analyzed which is very similar to a recent study using the NHANES dataset, there are some discrepancies on prevalence rates of pre- and hypertensive subjects. It is likely that the differences may be primarily because we excluded those who self-reported kidney diseases, diabetes or cardiovascular diseases in the current analyses while the previous study did not. In conclusion, our cross-sectional study found the association between high blood pressure and reduced renal function was modified by the albuminuria status among participants without diabetes, CKD or cardiovascular disease, excluding interference from medication use or dietary changes. Furthermore, our findings suggest this also could be true among those with a mildly reduced or normal kidney function. Further studies are warranted to confirm our findings and explore this promising possibility. Corticosteroids and other immunosuppressive drugs have been widely used for its treatment. However, these drugs may cause a number of side effects that can potentially be life-threatening. Interleukin -27 is a recently identified member of the IL-6/ IL-12 family. It is a heterodimeric cytokine consisting of 2 subunits, Epstein-Barr-induced gene 3 and IL-27p28. It has been shown to play an important role as an inhibitor of both Th1 and Th17 responses and may thus control autoimmune mediated inflammation. Recent studies have shown that systemic administration of exogenous IL-27 significantly inhibits the activity of experimental autoimmune encephalomyelitis, EAU and collagen-induced arthritis in animal models. In addition, endogenous production of IL-27 by retinal cells has been shown to inhibit the intraocular inflammation in EAU. IL-27p28 and EBI3 are secreted independently, and both subunits are not expressed by the same cells. The finding that the IL-27p28 can be secreted in the absence of EBI3 suggests that this subunit may have an independent function. Purified IL27p28, like heterodimeric IL-27, was capable of suppressing IL-17 production by CD4+ T cells in vitro. Expression of IL-27p28 has been shown to result in a modest delay in the onset and severity of EAE. Remarkable success of gene therapy has been achieved in human and animal models for various retinal diseases. The eye is an organ particularly suitable for gene therapy due to the following reasons. Various routes of delivery can be used to target layers in the eye under direct vision and the application of AAV vector leads to a long-term and stable gene transfer instead of having to use repeated injections and high dose administration of recombinant cytokines.