Author: BioactiveCompoundLibrary

This supervised analysis presumes that any meaningful differences are between the predetermined groups of samples. An unsupervised analysis uses no prior knowledge about how the samples are related. As an example, global hierarchical clustering was used to discover the interferon signature in the blood of some but not all SLE patients. Closer integration of biological… Continue reading To measure the statistical significance of differentially expressed genes between two groups of samples

Severe reductions in nephron number, characteristic of renal hypoplasia/dysplasia, are the leading cause of childhood renal failure. More subtle defects in nephron number have been associated with the development of adult-onset essential hypertension and chronic renal failure. The balance of GLI activator and repressor activities is critical during renal morphogenesis. Mutations that are predicted to… Continue reading Nephrons formed is directly related to the number of ureteric branches and their inductive capacity

A highly conserved, cystein rich domain, presumed to bind Wnts, in the absence of a transmembrane domain represents the structural requirement for a dominant negative molecule. It was thus suggested that sFRP-3 may sequester Wnts in the extra-cellular space and prevent binding to the Frizzled membrane receptors. How this may occur in molecular terms is… Continue reading The elucidation of the sequence of sFRP proteins immediately suggested their possible function

These transgenic models suffer axonopathy and tauopathy, respectively, but without appreciable neurodegeneration. Although data to answer this problem do not abound, we consider as major difference the observed microgliosis that is much more intense in the AAV-Tau model than in the AAV-APP mice. This is strongly reminiscent of our observations in inducible p25 mice that… Continue reading Microgliosis is spatially and temporally most closely associated with degenerating neurons in the AAV-tau models

The relation between the two defining pathologies in AD, and their relative contribution to cognitive defects, clinical symptoms, neurodegeneration, brain atrophy and dementia Dexrazoxane hydrochloride remains. Transgenic mice have been invaluable for understanding molecular mechanisms underlying amyloid peptide generation, but amyloid mice lack two major pathological features of AD, i.e. tauopathy and neuro-degeneration. Tauopathy is… Continue reading subject to academic debate obscures early diagnosis and hinders development of effective therapy