Author: BioactiveCompoundLibrary

In serum free conditions, and after a finite number of mitoses, they cease to divide and differentiate. In order to maintain them in a proliferative state, we have transduced primary human MSCs with the retroviral vector encoding immortalizing gene v-myc. Stable immortalized cell lines of human MSC as described in the present study should provide… Continue reading MSCs isolated from fetal bone marrow for more than years and found out that remain in a continuous proliferative state

It is well known that the plasma membrane and actin cytoskeleton are intimately connected, and that their association may occur in membrane microdomains enriched in cholesterol and sphingolipids, known as lipid rafts. Cytoskeletonassociated or cytoskeleton proteins such as actin, tubulin, myosin, a-actinin and supervillin form clusters and bind to membrane microdomains. Membrane rafts also concentrate… Continue reading Bending modulus can also be evaluated indirectly by fluctuation amplitude obtained by DM

We attempted to establish a functional role for Xvelo by depleting its RNA, and hence the protein, in oocytes. In the case of XveloFL the protein was so stable that we were unsuccessful, and not surprisingly there was no germ plasm phenotype. On the other hand it proved possible to reduce XveloSV considerably, resulting in… Continue reading Enables CST axons that arise from the undamaged hemisphere to extend collateral branches into the denervated side of the spinal cord

Although the protein localisation data depends solely on expression of exogenous Buc-GFP, it is highly likely that the endogenous protein behaves in a similar fashion, although it is not certain when the endogenous protein is actually expressed. While Buc RNA disappears from germ plasm in later oogenesis, it persists in a dispersed state at nearly… Continue reading As explained in the Introduction genetic evidence shows that its zebrafish homologue as well as germ plasm formation

Produced by bone marrow megakaryocytes, platelets are small anucleate elements of the blood that play a pivotal role in hemostasis. They are involved in fibrinolysis and Ginsenoside-F2 repair of the vessel wall, while circulating in the blood as sentinels of vascular integrity. Platelets lack genomic DNA but retain the ability for protein synthesis from cytoplasmic… Continue reading In order to fully characterize the platelet transcriptome without reference to previous